Search results for "Friedel-Crafts reactions"

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Organocatalytic asymmetric addition of naphthols and electron-rich phenols to isatin-derived ketimines: highly enantioselective construction of tetra…

2015

A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields (up to 99%) with excellent enantioselectivity (up to 99% ee). To the best of our knowledge, this transformation is the first highly enantioselective addition of naphthols to ketimines

ChemistryOrganocatalysisIsatinIsatin-derived ketiminesEnantioselective synthesisAsymmetric synthesisGeneral ChemistryNaphtholsGeneral MedicineCatalysisStereocenterReaccions químiqueschemistry.chemical_compoundThioureaCatàlisiOrganocatalysisFISICA APLICADAOrganic chemistryPhenolsFriedel-Crafts reactionsQuímica orgànicaAngewandte Chemie (International ed. in English)

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